Structural Immunoinformatics
HLA-Arena
HLA-Arena provides a customizable environment for the structural modeling and analysis of peptide-HLA complexes
Geometry prediction of peptide-HLAs
HLA-Arena is a wrapper around APE-Gen and DINC and uses both for peptide-HLA modeling
Binding energy prediction for peptides
HLA-Arena uses a combination of amino-acid sequence-based analysis and 3D structural analysis to determine binding energy predictions
Virtual screening for HLA binders
HLA-Arena is the first tool that provides a complete pipeline for virtual screening of peptides binding to HLAs
Customizable workflows for analysis
Every facet of HLA-Arena is customizable, so users can customize their own peptide identification workflows
Further Links
Check out our github repo here: Github
You can find the documentation here: Documentation
You can find the paper here:Paper
References
If you use HLA-Arena in your work, please cite the tool as shown:
D. A. Antunes, J. R. Abella, S. Hall-Swan, D. Devaurs, A. Conev, M. Moll, G. Lizée, and L. E. Kavraki, “HLA-Arena: a customizable environment for the structural modeling and analysis of peptide-HLA complexes for cancer immunotherapy,” JCO Clinical Cancer Informatics, vol. 4, pp. 623–636, Jul. 2020. PMID: 32667823, PMCID: 7397777